The design of subsea production system components such as flowlines, risers and jumpers, shares many similarities with oil production systems. The presence of multiphase flow is a unique feature of gas systems, that not only requires special consideration but can also be the key design driver, affecting fabrication and system cost. The multiphase flow through the pipe can result in different flow regimes, that can cause different types of vibrations on flowlines and jumpers. These flow-induced vibrations (FIV), result in significant fatigue damage that typically require the use of high-quality welds, with strict fabrication requirements. FIV of pipelines and jumpers also requires in-situ monitoring to confirm the design and manage the integrity. This presentation will focus on the FIV of flowline spans and jumpers, explain the importance and implications on design. The importance and use of structural response monitoring will be presented, providing example applications and describe the monitoring systems used. The presentation will also highlight the use of monitoring data to validate design and manage integrity.